Investigation of the secretion of glucagon for glucose intolerance
Not Applicable
Recruiting
- Conditions
- ormal glucose tolerance (NGT), Impaired glucose tolerance(IGT), Type 2 diabetes (T2DM)
- Registration Number
- JPRN-UMIN000019252
- Lead Sponsor
- Kobe university school of medicine, Diabetes and Endocrinoplogy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
Not provided
Exclusion Criteria
1)Type 1 DM 2)Pancreatic diabetes 3)Medical history of gastrointestinal tract surgery 4)Having insulin antibody(>10%) 5)Treatment with any long-acting insulin 6)Treatment with steroid 7)Impaired liver function, defined as alanine aminotransferase >2 times upper limit of normal(HBC or HCV infection) 8) Impaired renal function defined as eGFR <60ml/min 9) Severe cardiac dysfunction (> NYHA 3) 10)Cancer and medical history of cancer 11)Pregnancy or breast feeding 12)Known or suspected abuse of alcohol, narcotics or illicit drugs 13)Mental retardation or dementia or other inappropriate persons judged by investigators
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the area under the glucagon curve during hyperglycemic clamp among three groups (NGT,IGT and T2DM)
- Secondary Outcome Measures
Name Time Method Comparison of the area under the insulin curve during hyperglycemic clamp among three groups (NGT,IGT and T2DM)