Computer Modelling of the Cervical Spine Movements in Cervical Dystonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- comparison of bone marks positions (degrees) in patients ans control motions
研究概览
简要总结
Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia. The distribution of dystonic muscles is unique for each patient, explaining the variety of patterns encountered.
The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin injections and/or specific retraining therapy programmes. Therefore, analyzing the characteristics of abnormal head movements and identifying the dystonic muscles are the key points of these treatments.
To a better understanding of the posture and movement disorders of head and neck, we wish to establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy subjects built from images obtained with the "Cone Beam " system. Then we will compare the cervical posture and movements for each of ten CD patients matched in age and genre to the computer model. Comparison with patients' images in the axial plane reconstructed by computer with the 3-D computer model will lead to the description of various patterns of CD. Analysis of the musculoskeletal disturbances in CD should be a help to improve the localization of Botulinum Neurotoxin injection sites as well as retraining programmes.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Tonic form of focal or segmental cervical dystonia (diagnostic confirmed by a neurologist specialized in movement disorders) for CD patients, or absence of CD for control subjects
- •absence of treatment by botulinum neurotoxin, or last injection > 3 months
- •age > 18 and < 71 years
- •informed consent
- •medical insurance coverage
排除标准
- •CD mobile (clonic) and/or head tremor
- •patient unable to sit without moving the head during the examination (x-ray pictures with cone beam)
- •Other neurological disease with effect on the posture and/or movement of the cervical region
- •Pain or traumatism of the cervical region requiring medical or surgical treatment in the preceding 6 months
- •Pregnant or breast feeding patient
- •Participation in another research with a potential impact on evaluation criteria
- •patient under judiciary protection
结局指标
主要结局
comparison of bone marks positions (degrees) in patients ans control motions
时间窗: baseline
positions measured in degrees with computerized imaging
次要结局
未报告次要终点
