The influence of low frequency stimulation with a Dorsal Root Ganglion stimulator on peripheral blood flow in patients with Complex Regional Pain Syndrome and vasomotor disturbances.

• Conditions: Complex Regional Pain Syndrome; posttraumatic dystrophy; 10034606

• Registration Number: NL-OMON47944
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Patients diagnosed with CRPS according to the new IASP criteria
- Patients must have vasomotor disturbance; the skin temperature of the
affected extremity is at least 1°C colder than skin temperature of the
contralateral extremity. This will be measured using a thermography imaging
camera and determined using MatLab
- Patients must have a DRG stimulator for treatment of CRPS, that has been
implanted at least three months before inclusion
- Clinically the contralateral extremity must be without signs or symptoms in a
way that it can be used as a control.

Exclusion Criteria

- Age < 18 years
- Patients diagnosed with other disease that influences the peripheral blood
flow
- Patients using medication that influences peripheral blood flow
- DRG stimulator implanted within three months before inclusion

NB: of patients suffer from mitochondrial disease or porphyria the measurement
of mitoPO2 and mitoVO2 will be leaved out.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint of this study is the effect on peripheral blood flow.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters of this study are the mitoPO2 and mitoVO2. </p><br>