Exploring immunological control mechanisms of SARS-CoV-2 (COVID-19)
- Conditions
- U07.1COVID-19, virus identified
- Registration Number
- DRKS00021468
- Lead Sponsor
- Institut für Virologie Uniklinik Köln
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 710
Inclusion Criteria
General inclusion criteria
- Age =18 years
- In generally good physical condition (Karnofsky-Index =80%)
Additional inclusion criterion when a cumulative blood volume of >100 ml is planned to be drawn:
- Current or previous laboratory-confirmed SARS-CoV-2 infection
Exclusion Criteria
Exclusion criteria when a cumulative blood volume of >100 ml is planned to be drawn:
- Hemoglobin <10 g/dl
- Symptomatic cardiac disease (e.g., congestive heart failure NYHA =II, coronary artery disease)
- History of myocardial infarction
- COPD GOLD grade III-IV
- Body weight <45 kg (for a blood draw of =250 mL, a minimum body weight of 50 kg is required)
- <8 weeks (men) or <12 weeks (women) since last draw of a blood volume of =500 ml
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Prevalence (ELISA) (Baseline)<br>- Risk factors (Questionnaire) (Baseline)<br>- Antibody response (ELISA, neutralization assays) (Baseline, every 6-12 weeks)<br>- Cellular response (cytokine assays)<br>
- Secondary Outcome Measures
Name Time Method