Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 230
- 主要终点
- time to malignant recurrence
研究概览
简要总结
Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.
详细描述
One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. These individuals were retrospectively matched to 112 counterparts, who underwent liver surgery applying inflow and outflow vascular clamping only of the segment harboring the tumor, sparing the liver remnant from any I/R injury (control group). The two cohorts were compared regarding recurrence-free survival and overall survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •American Society of Anesthesiologists (ASA) distribution I to III
- •Patients scheduled for major liver resection (≥3 segments)
排除标准
- •patients with extrahepatic disease
- •patients with metastatic liver tumors
结局指标
主要结局
time to malignant recurrence
时间窗: from time of operation until time of malignant recurrence, assessed up to 15 years
recurrence-free survival
time to death
时间窗: from time of operation until time of death, assessed up to 20 years
overall survival
次要结局
- aspartate aminotrasferase (AST) levels(second postoperative day)
研究者
Dr Kassiani Theodoraki
Associate Professor of Anesthesiology
Aretaieion University Hospital