The Joint Effects of Turmeric, Black Seeds, Flaxseed and Medicago Sativa for relieving symptoms of knee osteoarthritis: A Phase 1-2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Tabriz University of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2023年2月7日

适应症

试验速览

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•At least 6 months of diagnosis of knee osteoarthritis, and whose OA diagnosis meets the American College of Rheumatology criteria
•Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale baseline value of = 9 (0-20 scale)
•Functional Capacity Classification of I-III
•Radiograph evidence of OA in the target knee with a Kellgren-Lawrence score of 2 or 3
•Morning stiffness of <30 min duration or crepitus on active motion, which is present upon examination

•Evidence of other conditions or diseases of the skin or joints
•Evidence of partial or complete knee joint replacement or anticipated joint replacement in the target knee
•Contraindications to the use of non-steroidal anti-inflammatory drugs (NSAIDs) or who use anticoagulant therapy that prohibits them from using NSAIDs
•Pregnancy, planning to become pregnant or breastfeeding during the study period
•Ischemic heart disease, heart failure, end-stage cirrhosis, end-stage renal failure, or psychiatric conditions that prevent an adequate evaluation of the study outcomes
•Insufficient cognitive functioning to participate and complete the questionnaires
•Unable or unwilling to follow up and complete the study pathway,
•A history or diagnosis of other arthritic conditions, such as rheumatoid arthritis, joint and bone deformities, fibromyalgia and/or other inflammatory and immune system disorders
•Type I or II diabetes or obesity (body mass index = 39)
•Suffering from painful conditions or frequent headaches requiring the use of systemic opiates or derivatives, or the need for additional NSAID or COX-2 inhibitors
•Receiving systemic or intra-articular corticosteroid injections.
•Having active cancer undergoing treatment that prevents the evaluation of the outcome measures

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