Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease

National Center for Research Resources (NCRR)0 个研究点目标入组 40 人开始时间: 1992年10月1日最近更新: 2005年6月24日

适应症

试验速览

阶段: 2 期
状态: 已完成
发起方
入组人数: 40

研究概览研究设计入排标准研究者记录与标识符相似试验

研究概览

简要总结

OBJECTIVES:

I. Evaluate the effects of androgen suppression with leuprolide and androgen replacement with testosterone enanthate on muscle strength in men with Kennedy's disease or other motor neuron disease.

详细描述

PROTOCOL OUTLINE:

All patients receive androgen suppression with leuprolide acetate injections every 4 weeks for 6 months, plus hormone replacement therapy with testosterone enanthate injections every week for 24 weeks.

研究设计

研究类型: Interventional
主要目的: Treatment

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: Male
接受健康志愿者: 否

入选标准

•PROTOCOL ENTRY CRITERIA:
•-Disease Characteristics--
•Men aged 18 and over with motor neuron disease, i.e.:
•X-linked spinal and bulbar muscular atrophy (Kennedy's disease)
•Confirmed by androgen receptor, exon-1 mutation genotype
•Amyotrophic lateral sclerosis
•Spinal muscular atrophy
•Significant muscle weakness on manual muscle testing
•No prisoners
•No mental disability

排除标准

未提供

研究者

发起方

National Center for Research Resources (NCRR)

申办方类型

Nih

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