NCT01296919Unknown不适用
New Insights on the Clinical Significance of the Uncinate Process Histopathology in Patients With Chronic Rhinosinusitis
Assuta Hospital Systems1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2010年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
研究概览
简要总结
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.
详细描述
The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with chronic rhinosinusitis who:
- •Failed conservative medical treatment.
- •Stopped treatment (topical or systemic corticosteroids) at least two months before endoscopic sinus surgery.
- •Had a Lund-MacKay CT score of 2 and higher of 24 available.
排除标准
- •Immunosuppressed patients.
- •Patients in whom a pathologic evaluation of the middle turbinate was necessary (e.g., suspected neoplastic disorder).
- •Patients with a Lund-MacKay CT score < 2 of 24 available.
- •Pregnant women.
- •Patients who underwent prior endoscopic sinus surgery.
研究者
研究点 (1)
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