Prevalence of MTHFR Polymorphisms in Venous Disease

Completed

• Conditions: Thrombosis; MTHFR; Varicose Veins; Venous Disease

• Registration Number: NCT01993914
• Lead Sponsor: Health Diagnostic Laboratory, Inc.

Brief Summary

The etiologies of varicose veins and the progression to more serious forms of chronic venous disease and identification of appropriate diagnostic tests to better aid patient management by identifying individuals who may benefit from more aggressive treatment and/ or prophylactic measures.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Study First Submitted: 2013-11-19
• Study First Submitted QC: 2013-11-19
• Study First Posted: 2013-11-25
• Status Verified: 2014-11
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Last Update Submitted: 2014-11-14
• Last Update Posted: 2014-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age 18 or over
• No venous disease (N=30); or C2-C3 venous disease (N=30); or C4-C6 venous disease (N=30)

Exclusion Criteria

• Pregnancy

• Cancer

• Chronic obstructive pulmonary disease (COPD)

• Any systemic inflammatory disease

• Any of the following within the previous 30 days:

  • Trauma
  • Any surgery
  • Periods of prolonged inactivity

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of MTHFR mutation between patients	Baseline	Determine whether the prevalence of the MTHFR mutation differs between patient with varicose veins compared to controls and with or without superficial vein thrombosis.

Trial Locations

Locations (1)

The Elite Laser Vein Center; 🇺🇸 Los Angeles, California, United States