Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Not Applicable

Completed

• Conditions: Absorption
• Interventions: Dietary Supplement: Tocotrienol

• Registration Number: NCT01185769
• Lead Sponsor: Malaysia Palm Oil Board

Brief Summary

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

Detailed Description

There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Study Timeline

• Study Start: 2009-09
• Primary Completion: 2009-09
• Study Completion: 2009-09
• Status Verified: 2010-08
• Study First Submitted: 2010-08-19
• Study First Submitted QC: 2010-08-19
• Last Update Submitted: 2010-08-19
• Study First Posted: 2010-08-20
• Last Update Posted: 2010-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• male aged 22-25
• body mass index 18.5 < X < 30 kg/m2
• plasma cholesterol < 5.2 mmol/L,
• TAG < 1.7 mmol/L

Exclusion Criteria

• history of cardiovascular disease
• diabetic
• body mass index < 18.5 or > 30 kg/m2
• plasma cholesterol > 5.2 mmol/L,
• TAG > 1.7 mmol/L
• hypertension
• currently taking Vitamin E supplement
• current use of medication
• smoking.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High fat	Tocotrienol	500 mg of tocotrienol will be administered at single dose after consumption of high fat diet
Low fat	Tocotrienol	500 mg of tocotrienol will be administered at single dose after consumption of low fat diet

Primary Outcome Measures

Name	Time	Method
Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol	0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal

Trial Locations

Locations (1)

Malaysian Palm Oil Board; 🇲🇾 Bangi, Selangor, Malaysia