Mechanism of Absorption and Distribution of Tocotrienols Under Different Food Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol
研究概览
简要总结
Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols
详细描述
There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 22 Years 至 25 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male aged 22-25
- •body mass index 18.5 < X < 30 kg/m2
- •plasma cholesterol < 5.2 mmol/L,
- •TAG < 1.7 mmol/L
排除标准
- •history of cardiovascular disease
- •body mass index < 18.5 or > 30 kg/m2
- •plasma cholesterol > 5.2 mmol/L,
- •TAG > 1.7 mmol/L
- •hypertension
- •currently taking Vitamin E supplement
- •current use of medication
结局指标
主要结局
Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol
时间窗: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal
次要结局
未报告次要终点