Brain Balance Study

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria: Enrollment Criteria for Participant with TBI (TBI+ group) Inclusion criteria - Age 50-65. People of this age normally do not exhibit substantial balance or cognitive impairments, so observing a clear deficit between groups will provide compelling evidence of a TBI-related effect. This younger old age group will also help to avoid other comorbid health conditions of older age that would increase variability (uncertainty) in the data set. - Prior history of moderate closed-head TBI at least 10 years prior to study enrollment. Single or multiple TBIs are acceptable. All participants who self-report a prior TBI will complete a standardized interview called the Ohio State University TBI Identification Method (OSU TBI-ID) to characterize and confirm the occurrence of a prior moderate TBI. Moderate TBI will be defined as any of the following: - loss of consciousness from 30 minutes to 24 hours - and/or alteration of consciousness/mental state for greater than 24 hours - and/or post-traumatic amnesia for >1 to <7 days - and/or abnormal structural imaging confirmed by medical records - Affirmative response to the question: At the present time, do you consider yourself to be fully recovered from the TBI? - Score on the Activities Specific Balance Confidence Scale of 90 or higher (out of 100 possible points), which indicates absence of self-reported balance/mobility deficits. - Score of 19 or higher on the telephone version of the Montreal Cognitive Assessment, which indicates absence of major cognitive impairment. - living in the community and able to travel to the research site Exclusion Criteria: Enrollment Criteria for Participant with TBI (TBI+ group) Exclusion criteria - Neurological injury or disease other than prior history of moderate TBI - Current clinically significant post-traumatic stress disorder (PCL score >30) - severe arthritis, such as awaiting joint replacement, that would interfere with participation balance/mobility tasks - Current substance abuse - Current uncontrolled major depressive episode, history of severe psychiatric illness unrelated to TBI (e.g., bipolar 1 or schizophrenia). - severe obesity (body mass index > 35) - unstable cardiovascular disease (for example, recent angina or uncontrolled high blood pressure) - lung disease requiring use of supplemental oxygen - renal disease requiring dialysis - serious uncontrolled diabetes - terminal illness - myocardial infarction or major heart surgery in the previous year - cancer treatment in the past year, except for nonmelanoma skin cancers and cancers having an excellent prognosis (e.g., early stage breast or prostate cancer) - uncontrolled hypertension at rest (systolic > 180 mmHg and/or diastolic > 100 mmHg) - bone fracture in the previous year - hip joint replacement or metal implants that would preclude accurate assessment of lean mass or hip bone mineral density - Use of any pharmacologic agents (within past 180-days) that are known to influence BMD, including anti-resorptive or bone anabolic therapies, any compounded or over-the-counter androgenic hormone or androgen precursor, clomiphene, aromatase inhibitors, anti-estrogen or estrogen treatment, or growth hormone? - Chronic use of systemic glucocorticoids >7.5 mg/d prednisone equivalent (e.g., hydrocortisone 30 mg, methylprednisolone 6 mg, or dexamethasone 1.2 mg) - current participation in physical therapy for lower extremity function - current enrollment in a clinical trial that might jeopardize safety or scientific integrity of either trial - unable to communicate sufficiently with study personnel, and/or non-English speaking - other medical conditions other that would adversely affect balance, cognition, or oculomotor function. - clinical judgment of investigative team regarding safety or non-compliance.