Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Glioblastoma
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
- Enrollment
- 599
- Locations
- 27
- Primary Endpoint
- Molecular profiling on frozen samples
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This pro - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years. The different research focusses are:
- Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1)
- Identification of molecular tumor characteristics in long-term survivors (Focus 2)
- Assessment of therapy-related parameters, including neuro-toxicity (Focus 3)
- Immunological studies (Focus 4)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 years at diagnosis
- •Histopathological diagnosis of glioblastoma (reference histology available) and
- •Survival \>5 years from diagnosis
- •Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
- •Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients
Exclusion Criteria
- •Not applicable
Outcomes
Primary Outcomes
Molecular profiling on frozen samples
Time Frame: 1 year from last patient in
Samples will be subjected to microarray-based expression profiling
Molecular profiling on FFPE samples
Time Frame: 1 year from last patient in
Profiling for cytosine-phosphate-guanosine (CpG) methylation patterns using the Illumina 850k bead array platform
Overall Survival
Time Frame: 1 year from last patient in
Proteome profiling
Time Frame: 1 year from last patient in
Tumor cells will be microdissected from frozen sections and prepared for high-resolution mass spectrometry