Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma
- Conditions
- Glioblastoma
- Registration Number
- NCT03770468
- Brief Summary
This pro - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years. The different research focusses are:
* Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1)
* Identification of molecular tumor characteristics in long-term survivors (Focus 2)
* Assessment of therapy-related parameters, including neuro-toxicity (Focus 3)
* Immunological studies (Focus 4)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 599
- Age > 18 years at diagnosis
- Histopathological diagnosis of glioblastoma (reference histology available) and
- Survival >5 years from diagnosis
- Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
- Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients
- Not applicable
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Molecular profiling on frozen samples 1 year from last patient in Samples will be subjected to microarray-based expression profiling
Molecular profiling on FFPE samples 1 year from last patient in Profiling for cytosine-phosphate-guanosine (CpG) methylation patterns using the Illumina 850k bead array platform
Overall Survival 1 year from last patient in Proteome profiling 1 year from last patient in Tumor cells will be microdissected from frozen sections and prepared for high-resolution mass spectrometry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (27)
Dana-Farber Cancer Institute & Harvard Medical School
🇺🇸Boston, Massachusetts, United States
Universitaetsklinikum Wien - AKH uniklinieken
🇦🇹Vienna, Austria
Hopitaux Universitaires Bordet-Erasme
🇧🇪Brussel, Belgium
CHU Lyon - Hopital neurologique Pierre Wertheimer
🇫🇷Bron, France
CHRU de Lille
🇫🇷Lille, France
Hopitaux de Marseille - Hôpital de La Timone (APHM)
🇫🇷Marseille, France
Institut du Cancer de Montpellier
🇫🇷Montpellier, France
CHU de Nice - Hopital Pasteur
🇫🇷Nice, France
Hopitaux de Paris - Hopital Saint-Louis
🇫🇷Paris, France
Hopitaux de Paris - La Pitie Salpetriere
🇫🇷Paris, France
Scroll for more (17 remaining)Dana-Farber Cancer Institute & Harvard Medical School🇺🇸Boston, Massachusetts, United States