Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 599
- 试验地点
- 27
- 主要终点
- Molecular profiling on frozen samples
研究概览
简要总结
This pro - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years. The different research focusses are:
- Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1)
- Identification of molecular tumor characteristics in long-term survivors (Focus 2)
- Assessment of therapy-related parameters, including neuro-toxicity (Focus 3)
- Immunological studies (Focus 4)
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years at diagnosis
- •Histopathological diagnosis of glioblastoma (reference histology available) and
- •Survival >5 years from diagnosis
- •Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
- •Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients
排除标准
- •Not applicable
结局指标
主要结局
Molecular profiling on frozen samples
时间窗: 1 year from last patient in
Samples will be subjected to microarray-based expression profiling
Molecular profiling on FFPE samples
时间窗: 1 year from last patient in
Profiling for cytosine-phosphate-guanosine (CpG) methylation patterns using the Illumina 850k bead array platform
Overall Survival
时间窗: 1 year from last patient in
Proteome profiling
时间窗: 1 year from last patient in
Tumor cells will be microdissected from frozen sections and prepared for high-resolution mass spectrometry
次要结局
未报告次要终点