Dose Responsive Study of Ringer's Lactate Solution in Prevention of Post-induction Hypotension Predicted by Inferior Vena Cava Collapsibility Index in Patients Receiving General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Effective dose of Ringer's lactate solution to prevent post-induction hypotension
研究概览
简要总结
To assess the dose responsiveness of ringer lactate solution in prevention of post-induction hypotension predicted by Ultrasound guided Inferior Vena Cava diameter in patients receiving General anesthesia.
OBJECTIVES Primary - To find the optimum preloading dosage of Ringer Lactate to prevent post induction hypotension.
Secondary - To find the predictive incidence of Post-induction hypotension according to age, gender, type of surgery and comorbidities.
详细描述
All patients, after Ultrasonographic Inferior vena cava collapsibility index calculation, will receive Lactated Ringer's solution as per body weight and as per their allocated group in the receiving area.
After induction inside the Operating Room, All patients will be monitored continuously using Electrocardiography, pulse oximetry, noninvasive Blood pressure measurement and capnography .
Heart rate, Systolic - Diastolic - Mean blood pressure, Oxygen saturation will be monitored as follows :
- Baseline parameters - Prior to administration of intravenous Ringer's lactate solution
- T0 (after administration of intravenous Ringer's lactate solution but prior to induction of anaesthesia),
- T1-T10 (every minute for first 10 mins after induction of anaesthesia) Our institutional standard practice of induction of Anaesthesia with Fentanyl (2 μg/kg), Propofol (2 mg/kg) and Vecuronium (0.1mg/kg ) will be followed and intubation will be done only after first 10 mins post induction.
Amount of Mephentermine needed to correct hypotension despite RL infusion will also be calculated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years American Society of Anesthesiologists (ASA) Physical status classification system group I and II Elective surgery under General anesthesia
排除标准
- •Age <18 and > 65 American Society of Anesthesiologists (ASA) Physical status classification system group III and IV Systolic blood pressure ≥ 180 mmHg Systolic blood pressure < 90 mmHg Pregnant women Patients with abdominal mass or ascites Emergency surgery
研究组 & 干预措施
RL 10
Patients of this group will receive Ringer's lactate (RL) 10ml/kg
干预措施: RL 10ml/kg (Other)
RL 15
Patients of this group will receive 15ml/kg of Ringer's lactate solution
干预措施: RL 15ml/kg (Other)
结局指标
主要结局
Effective dose of Ringer's lactate solution to prevent post-induction hypotension
时间窗: 15 months
This study will try to find out the effective dose of Ringer's lactate solution in ml/Kg that will prevent hypotension after induction of anaesthesia in study population
次要结局
- Effect of age, gender, types of surgery and comorbid conditions on post-induction hypotension(15 months)
研究者
Abhishek Chatterjee
Consultant
Tata Main Hospital