Brain Regulation of Appetite in Twins

Completed

• Conditions: Appetite; Obesity
• Interventions: Device: Functional Magnetic Resonance Imaging; Radiation: Dual Energy X-ray absorptiometry; Other: Questionnaires; Other: Mood and Appetite Ratings; Other: Test Meals; Other: Computer Tests; Procedure: Intravenous Catheter (IV) placement

• Registration Number: NCT02483663
• Lead Sponsor: University of Washington

Brief Summary

Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2015-06-17
• Study First Submitted QC: 2015-06-24
• Study First Posted: 2015-06-29
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-25
• Last Update Posted: 2017-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

• Ability and willingness to come with their twin to the University of Washington (Seattle)
• Additional Criteria for Aim 1 random sample only: Member of randomly selected MZ pair or
• Additional criteria for Aim 2 random sample only: One member of MZ or same-sex DZ pair with BMI of at least 30 kg/m^2
• Additional criteria for Aim 3 sample only: Member of randomly selected MZ pair, and not BMI discordant ≥ 5 kg/m^2

Exclusion Criteria

• History of weight loss surgery or active participation in weight loss program
• Major medical problem (e.g., diabetes, cancer)
• Current use of weight loss medications or other medications known to alter appetite
• Pregnancy or menopause
• MRI contraindication (i.e., implanted metal, claustrophobia)
• Lifetime eating disorder
• Current smoking
• Current heavy alcohol use (≥2 drinks per day for females and ≥ 3 drinks per day for males)
• Self-reported weight >330 pounds at time of phone screening. MRI cannot accommodate all shapes or weights. Inability to have MRI does not exclude subject from participating in other study procedures.
• BMI < 18.5 or > 45 kg/m^2
• Allergies to study foods or inability to taste
• Twins were raised apart
• Co-twin not eligible or not willing to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
27 Dizygotic Pairs	Functional Magnetic Resonance Imaging	-
27 Monozygotic Pairs	Intravenous Catheter (IV) placement	-
27 Dizygotic Pairs	Dual Energy X-ray absorptiometry	-
27 Dizygotic Pairs	Questionnaires	-
27 Monozygotic Pairs	Dual Energy X-ray absorptiometry	-
27 Monozygotic Pairs	Mood and Appetite Ratings	-
27 Monozygotic Pairs	Computer Tests	-
27 Monozygotic Pairs	Test Meals	-
27 Dizygotic Pairs	Intravenous Catheter (IV) placement	-
27 Monozygotic Pairs	Functional Magnetic Resonance Imaging	-
27 Monozygotic Pairs	Questionnaires	-
27 Dizygotic Pairs	Mood and Appetite Ratings	-
27 Dizygotic Pairs	Test Meals	-
27 Dizygotic Pairs	Computer Tests	-

Primary Outcome Measures

Name	Time	Method
Objective satiety: caloric and macronutrient intake	Baseline
Meal-induced nutrient and hormonal changes in plasma (insulin, GLP-1, ghrelin, glucose)	Baseline
Brain activation during fMRI in satiety-related regions	Baseline
Body composition: fasting leptin and dual energy X-ray absorptiometry (DXA)	Baseline
DNA evaluation of FTO genotypes	Baseline
Subjective satiety: visual analog scale (VAS) scores and appeal ratings	Baseline

Trial Locations

Locations (1)

University of Washington; 🇺🇸 Seattle, Washington, United States