Brain Regulation of Appetite in Twins
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 122
- 试验地点
- 1
- 主要终点
- Objective satiety: caloric and macronutrient intake
研究概览
简要总结
Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ability and willingness to come with their twin to the University of Washington (Seattle)
- •Additional Criteria for Aim 1 random sample only: Member of randomly selected MZ pair or
- •Additional criteria for Aim 2 random sample only: One member of MZ or same-sex DZ pair with BMI of at least 30 kg/m^2
- •Additional criteria for Aim 3 sample only: Member of randomly selected MZ pair, and not BMI discordant ≥ 5 kg/m^2
排除标准
- •History of weight loss surgery or active participation in weight loss program
- •Major medical problem (e.g., diabetes, cancer)
- •Current use of weight loss medications or other medications known to alter appetite
- •Pregnancy or menopause
- •MRI contraindication (i.e., implanted metal, claustrophobia)
- •Lifetime eating disorder
- •Current smoking
- •Current heavy alcohol use (≥2 drinks per day for females and ≥ 3 drinks per day for males)
- •Self-reported weight >330 pounds at time of phone screening. MRI cannot accommodate all shapes or weights. Inability to have MRI does not exclude subject from participating in other study procedures.
- •BMI < 18.5 or > 45 kg/m^2
- •Allergies to study foods or inability to taste
- •Twins were raised apart
- •Co-twin not eligible or not willing to participate
结局指标
主要结局
Objective satiety: caloric and macronutrient intake
时间窗: Baseline
Meal-induced nutrient and hormonal changes in plasma (insulin, GLP-1, ghrelin, glucose)
时间窗: Baseline
Brain activation during fMRI in satiety-related regions
时间窗: Baseline
Body composition: fasting leptin and dual energy X-ray absorptiometry (DXA)
时间窗: Baseline
DNA evaluation of FTO genotypes
时间窗: Baseline
Subjective satiety: visual analog scale (VAS) scores and appeal ratings
时间窗: Baseline
次要结局
未报告次要终点
研究者
Ellen Schur, MD, MS
Associate Professor, Medicine
University of Washington