Expression and Clinical Significance of PD-L1 and BRAF Expression in Nasopharyngeal Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Response rate
研究概览
简要总结
The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study the investigators investigated alterations in PD-L1, BRAF and EGFR by using immunohistochemistry analysis in a cohort of consecutively enrolled NPC patients.
详细描述
NPC is a common type cancer in Macau and Southern China. The role of PD-L1 in NPC remains controversial. There many reasons behind these inconsistent findings. We used the SP263 antibody with the standard cut off value of 1% and 5%, which is frequently used for lung cancer and other cancer types. We also plan to include over 150 patients, which will be the largest study in NPC. This will help us to gain insights in NPC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Above 18 years of age
- •Locally advanced (stage IIIB) or metastatic (stage IV) NPC
- •Fresh-frozen tissue samples were available were included
- •After treatment with curative surgery or radiotherapy in Macau
- •With follow up data were available
排除标准
- •Enrolment in studies that prohibit any participation in this observational study
结局指标
主要结局
Response rate
时间窗: Followed up with 12 months after last patient in
Efficacy after radiation
次要结局
- Survival rate(Followed up with 12 months after last patient in)