ACTRN12615001273572终止4 期
Acetyl Cysteine In Schizophrenia Resistant To Clozapine: A Double-Blind Randomised Placebo-Controlled Trial Targeting Negative Symptoms
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 85
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •To be included the participants will be required to meet DSM5 criteria for SZ and:
- •- Have been on clozapine at an adequate dose, ascertained by a serum level of >350mcg/L for at least 6 months with residual symptom
- •- Have a PANSS score of 60 or at least two negative symptom items of >4
- •- Have the capacity to consent to the study
- •- Aged between 18 and 65 years
- •- Be utilising effective contraception if female and of childbearing age
排除标准
- •- Participants who are currently taking NAC
- •- Participants who are allergic to NAC or any component of the preparation
- •- Inability to comply with either the requirements of informed consent or the treatment protocol.
- •- People taking nitro-glycerine
- •- Diabetics on insulin replacement
- •- People taking Selenium or Vitamin E
研究者
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