Effect of the Intensive Intervention "Hand-Arm Bimanual Intensive Therapy Including Lower Extremities" (HABIT-ILE) in Chronic (> 6 Months) Adults With Acquired Brain Damage (Stroke)

简要总结

详细描述

主要结局

次要结局

• Changes on speed/accuracy trade-off during a bimanual reaching task (bi-SAT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes on bimanual coordination during a bimanual reaching task (bi-CO)(baseline, 3 weeks and 13 weeks after baseline)
• Changes on errors during a bimanual reaching task (bi-error)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in finger force tracking dexterity(baseline, 3 weeks and 13 weeks after baseline)
• Changes on the visuospatial short term working memory assessed by the "Corsi block-tapping test"(baseline, 3 weeks and 13 weeks after baseline)
• Changes on bimanual smoothness during a bimanual reaching task (bi-smoothness)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in Fractional Anisotropy (FA) of the corticospinal tract from the motor cortex to the cerebellar peduncle(baseline, 3 weeks and 13 weeks after baseline)
• Changes on the metrics of the corticospinal tract from the motor cortex to the cerebellar peduncle using the NODDI model(baseline, 3 weeks and 13 weeks after baseline)
• Changes in multifinger tapping dexterity(baseline, 3 weeks and 13 weeks after baseline)
• Changes on the Axial, Radial and Mean Diffusivity (AD, RD, MD) of the corticospinal tract from the motor cortex to the cerebellar peduncle(baseline, 3 weeks and 13 weeks after baseline)
• Changes on force during a bimanual reaching task (bi-Force)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in upper extremities sensorimotor functions assess by the Fugl-Meyer Assessment (FMA-UE)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in the Six Minutes' Walk Test (6MWT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in Canadian Occupational Performance Measure (COPM)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in the Stroke Impact Scale (SIS)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in cortical thickness of the brain's gray matter(baseline, 3 weeks and 13 weeks after baseline)
• Changes in brain white matter microstructure (WM-μs) using the Microstructure Fingerprinting model(baseline, 3 weeks and 13 weeks after baseline)
• Changes in unimanual dexterity assessed by the Box & Block test (BBT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in visual neglect assessed by the Bells Test(baseline, 3 weeks and 13 weeks after baseline)
• Changes in the Montreal Cognitive Assessment (MoCA) test(baseline, 3 weeks and 13 weeks after baseline)
• Changes on the metrics of the corticospinal tract from the motor cortex to the cerebellar peduncle using the DIAMOND model(baseline, 3 weeks and 13 weeks after baseline)
• Changes in resting-state functional connectivity(baseline, 3 weeks and 13 weeks after baseline)
• Changes in upper extremities motor functions assess by the Wolf Motor Function Test (WMFT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in activities of daily living assessed by ACTIVLIM-Stroke Questionnaire(baseline, 3 weeks and 13 weeks after baseline)
• Changes in the modified Rankin Scale (mRS) for neurologic disability(baseline, 3 weeks and 13 weeks after baseline)
• Changes in executive functions assessed by the Trail Making Test (TMT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in activities of daily living assessed by ABILHAND Questionnaire(baseline, 3 weeks and 13 weeks after baseline)
• Changes in inhibitory control assessed by the Stroop Color and Word Test (SCWT)(baseline, 3 weeks and 13 weeks after baseline)
• Changes in the Wechsler Adult Intelligence Scale (WAIS-III)(baseline, 3 weeks and 13 weeks after baseline)