Automated Imaging Differentiation of Parkinsonism

Active, not recruiting

• Conditions: Multiple System Atrophy, Parkinson Variant; Parkinson Disease; Progressive Supranuclear Palsy
• Interventions: Diagnostic Test: AIDP

• Registration Number: NCT05913687
• Lead Sponsor: University of Florida

Brief Summary

The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-22
• Study First Submitted: 2023-06-13
• Study First Submitted QC: 2023-06-13
• Study First Posted: 2023-06-22
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-08
• Last Update Posted: 2024-10-11
• Primary Completion: 2026-03-31
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 315

Inclusion Criteria

• Parkinson's disease diagnosis within 5-9 years of baseline date
• MSAp diagnosis
• PSP diagnosis

Exclusion Criteria

• metal implants in the body that preclude an MRI (pacemaker, metallic clip, neurostimulator, etc)
• claustrophobia
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Progressive Supranuclear Palsy	AIDP	Clinically diagnosed Progressive Supranuclear Palsy
Multiple System Atrophy, Parkinsonian variant	AIDP	Clinically diagnosed Multiple System Atrophy, Parkinsonian variant
Parkinson's disease	AIDP	Clinically diagnosed Parkinson's disease

Primary Outcome Measures

Name	Time	Method
Predicted diagnosis accuracy	12-18 months	utilizing the automated imaging differentiation of Parkinsonism (AIDP) tool to predict diagnosis compared to the expertise of two movement disorder specialists

Trial Locations

Locations (21)

University of Alabama at Birmingham; 🇺🇸 Birmingham, Alabama, United States

University of California San Diego; 🇺🇸 La Jolla, California, United States

University of California San Francisco; 🇺🇸 San Francisco, California, United States

University of Florida; 🇺🇸 Gainesville, Florida, United States

University of South Florida; 🇺🇸 Tampa, Florida, United States

Augusta University; 🇺🇸 Augusta, Georgia, United States

Northwestern University; 🇺🇸 Chicago, Illinois, United States

University of Chicago; 🇺🇸 Chicago, Illinois, United States

University of Kentucky; 🇺🇸 Lexington, Kentucky, United States

Johns Hopkins University; 🇺🇸 Lutherville, Maryland, United States

Beth Israel Deaconess Medical Center; 🇺🇸 Boston, Massachusetts, United States

Massachusetts General Hospital; 🇺🇸 Charlestown, Massachusetts, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States

Washington University in St. Louis; 🇺🇸 Saint Louis, Missouri, United States

Albany Medical College; 🇺🇸 Albany, New York, United States

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States

Wake Forest University; 🇺🇸 Winston-Salem, North Carolina, United States

Pennsylvania State University; 🇺🇸 Hershey, Pennsylvania, United States

Ottawa Hospital Research Institute; 🇨🇦 Ottawa, Canada

Centre for Addiction and Mental Health; 🇨🇦 Toronto, Canada