Clinical investigation for the relation between dose amounts of antipsychotics and skin carbonylstress condition.
- Conditions
- schizophrenia
- Registration Number
- JPRN-UMIN000018519
- Lead Sponsor
- Department of Psychiatry, Juntendo University, Faculty of Medicine,
- Brief Summary
We investigated the relationship among skin AGE levels, minimal response dose (MRD) with UVA for photosensitivity and the daily dose of antipsychotic agents in patients with schizophrenia and healthy controls. We enrolled 14 patients with schizophrenia and 14 healthy controls. Measurement of skin AGE levels was conducted with AGE scanner, a fluorometric method for assaying skin AGE levels. Measurement of MRD was conducted with UV irradiation device. Skin AGE levels and MRD at 24, 48 and 72 h in patients with schizophrenia showed a higher tendency for photosensitivity than in the controls, but the difference was statistically insignificant. Multiple linear regression analysis using skin AGE levels failed to show any influence of independent variables. MRD did not affect skin AGE levels. Photosensitivity to UVA in patients with schizophrenia recieving treatment with antipsychotic agents might not be affected by skin AGE levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 48
Not provided
(1) severe patinets who can not understand the mean of present study fully. (2) Patients with porphyria and xeroderma pigmentosum. (3) Patients with polypharmacy more than three. (4) Patients with diabetus mellitus. (5) Patinetns with atopic dermatitis. (6) Patients with renal failure. (7) BMI > 30.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of skin carbonylstress using TruAge Scanner. Measurement of minimum response dose using UV-mate.
- Secondary Outcome Measures
Name Time Method