Greifswalder microbiome analysis colorectal cancer

Recruiting

• Conditions: Malignant neoplasm of rectosigmoid junction; Malignant neoplasm of rectum; Malignant neoplasm of colon; C18; C19; C20

• Registration Number: DRKS00025336
• Lead Sponsor: niversitätsklinikum Greifswald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

histologically confirmed CRC, or suspicion of CRC
- Age greater than or equal to 18 years

Exclusion Criteria

- Pregnancy/ nursing women
- Patients unable to give consent
- Secondary neoplasia < 5 years prior to study inclusion.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
16sRNA analysis of the microbiome (stool at initial diagnosis and postoperatively at primary surgery, or before neoadj. therapy and after completion, tumor tissue intraoperatively) in patients with CRC.

Secondary Outcome Measures

Name	Time	Method
Overall survival<br>Tumor-free survival<br>Changes of the microbiome under therapy by 16sRNA analysis