The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection.
试验速览
- 阶段
- 不适用
- 入组人数
- 1,821
- 试验地点
- 1
- 主要终点
- Relationship between eradication rate (%) of therapy regimen and influencing factors (eg. sex, age, diagnosis, MIC).
研究概览
简要总结
Clarithromycin (CLA)、amoxicillin (AMO)、metronidazole (MET)、levofloxacin (LEV) and tetracycline (TET) are commonly used antibiotics for Helicobacter pylori (Hp) therapy. However, the efficacy of treatment for Helicobacter pylori infection has decreased due to increasing resistance to CLA, MET and LEV. Studies had reported that beside antibiotics resistance, other factors such as age, sex, underlying disease, etc. may also affect the treatment efficacy. In some cases, when the MIC values were beyond the breakpoint, H. pylori strains with lower MIC value had better eradication than the ones with higher MIC value. However, few study investigated the relationship between MIC values and treatment outcome.
The investigators aimed to analyze the impact of influencing factors, especially minimal inhibitory concentration (MIC) value, on the efficacy of different treatment regimens.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients (aged ≥ 20 years old) with H. pylori infection between Jan. 1994 to Mar. 2018
排除标准
- •without antibiotics susceptible test result, without treatment outcome, history of any gastrointestinal surgery, serious concomitant (renal failure, liver cirrhosis, heart failure and disease need immunosuppressant for therapy.
研究组 & 干预措施
CLA triple therapy
Patients with clarithromycin-containing triple therapy
干预措施: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole (Drug)
MET triple therapy
Patients with metronidazole-containing triple therapy
干预措施: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole (Drug)
Concomitant therapy
Patients with concomitant therapy
干预措施: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole (Drug)
Sequential therapy
Patients with sequential therapy
干预措施: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole (Drug)
结局指标
主要结局
Relationship between eradication rate (%) of therapy regimen and influencing factors (eg. sex, age, diagnosis, MIC).
时间窗: 4 weeks after treatment finished.
次要结局
未报告次要终点