Randomised controlled trial of routine replacement of peripheral cannulae versus removal on clinical indicatio

Not Applicable

Completed

• Conditions: Phlebitis associated with intravenous cannulation; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12608000421336
• Lead Sponsor: Griffith University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-08-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 754

Inclusion Criteria

Peripheral cannulae in situ as part of routine clinical care for 3 days, written consent

Exclusion Criteria

Current bloodstream infection, immunosuppressed, planned intravenous device (IV) removal within 24 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Phlebitis: Phlebitis during catheterisation or up to 48 hours after catheter removal. Phlebitis defined as 2 or more of: pain, tenderness, erythema, swelling, purulence, and/or palpable venous cord.[Daily whilst cannulae is in situ]

Secondary Outcome Measures

Name	Time	Method
Catheter Related Bloodstream Infection (CRBSI): Bacteremia/fungemia with 1 positive blood culture obtained from a peripheral vein, clinical manifestations of infections (i.e.fever, chills, and/or hypotension), and no apparent source for the BSI except the catheter. One of the following should be present: a positive semiquantitative (>15 CFU/catheter segment) or quantitative (>103 Colony Forming Units/catheter segment catheter)<br>culture whereby the same organism (species and antibiogram) is isolated from the catheter segment and peripheral blood; simultaneous quantitative blood cultures with a >5:1 ratio IV versus peripheral; differential period of IV culture versus peripheral blood culture positivity of >2 hours.[Daily whilst cannulae in situ]