Development of a Predictive Index for Probable Depression Among Secondary School Students

• Conditions: Depression; Youth; Stress
• Interventions: Other: Observation

• Registration Number: NCT04063202
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

The present study aims to develop a new predictive index to predict future depression of adolescents by using factors including individual, interpersonal and environmental. The index can be used to predict likelihood of students who are non-probable depression cases convert into probable depression cases. In addition, the investigators also test the factors of depression remission. It can hence be used in school setting to identify high-risk students, and provide them with secondary interventions that are designed by considering modifiable significant variables identified in this unique, large-scale, longitudinal study.

Detailed Description

A 12-month longitudinal study will be conducted in secondary school settings.

The investigators will investigate incidence of probable depression (i.e., from non-depression, CESD\<16, at baseline to probable depression, CESD≥16, at month 12) and remission of probable depression.

The investigators will investigate factors that can prospectively predict new cases/remission of probable depression, including both well-documented risk/protective factors and some under-examined but potentially important local factors (e.g. school/academic stress, psychological resilience). The relative importance of the risk/protective factors at different socio-ecological levels will be compared and their combined effect will be identified.

Based on the selected factors, the investigators will derive a new prediction index called the Adolescent Depression Prediction Index (ADPI) in a model building sample and test its performance in predicting incidence of depression in a validation sample among secondary school students in Hong Kong.

Study Timeline

• Study First Submitted: 2019-08-19
• Study First Submitted QC: 2019-08-19
• Study First Posted: 2019-08-21
• Study Start: 2020-10-30
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-16
• Last Update Posted: 2022-03-17
• Primary Completion: 2023-08
• Study Completion: 2023-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 4799

Inclusion Criteria

• Secondary 1 (seventh year of formal education) to Secondary 4 Chinese students, who are studying local mainstream schools in Hong Kong.
• Able to read Chinese and speak either Cantonese or Mandarin.

Exclusion Criteria

• Eligible students whose parents refuse to give consent to take part in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-cases	Observation	Secondary school students (seventh to tenth years of education) without probable depression at baseline interview.

Primary Outcome Measures

Name	Time	Method
Incidence of probable depression	12 months	To examine the incidence of probable depression from non-depression (CESD\<16) at baseline to probable depression (CESD\>=16) at month 12.
Adolescent Depression Prediction Index (ADPI)	12 months	To develop a new prediction index ADPI and test test its performance in predicting incidence of depression.

Trial Locations

Locations (4)

Christian Alliance SW Chan Memorial College (Christian Alliance SW Chan Memorial Secondary School); 🇭🇰 Hong Kong, Hong Kong

Ho Ngai College ( Sponsored By Sik Sik Yuen); 🇭🇰 Hong Kong, Hong Kong

Kit Sam Lam Bing Yim Secondary Schoo; 🇭🇰 Hong Kong, Hong Kong

China Holiness Church Living Spirit College; 🇭🇰 Hong Kong, Hong Kong