Effect of fractional CO2 laser in combination with 5-fluorouracil cream compared to PDL laser in the treatment of hypertrophic and keloidal scars

Phase 3

Recruiting

• Conditions: Hypertrophic scar.; Hypertrophic scar; L91.0

• Registration Number: IRCT20190901044666N4
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Patients over 18 years old
Patients with a confirmed diagnosis of erythematous hypertrophic scar in the number of at least 2
The size of the waste should be at least 5x5 cm square or have a length of at least 5 cm
The patient is not pregnant or breastfeeding
During the last two months, the patient has not received any treatment for the lesions, including laser treatment, topical or injectable corticosteroids
The patient has no underlying diseases that lead to scar healing process; such as diabetes or weakened immune system
The patient's cooperation in carrying out therapeutic interventions and referring for all therapeutic sessions

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effectiveness of treatment on scar. Timepoint: Scar score measurement at the beginning of the study (before the start of the intervention) and after the end of the third session of the intervention (3 months later). Method of measurement: Vancouver scar scale (VSS) scoring method will be used to check the effectiveness of the treatment. This scale includes examination of 4 characteristics of the lesion, including: vascularity, pigmentation, height and flexibility, which are scored for each characteristic and the sum of all points will be checked in order to evaluate the improvement of the lesion.