Serial Changes of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Levels in Patients With Acute Respiratory Distress Syndrome
- Conditions
- Acute Respiratory Distress Syndrome
- Registration Number
- NCT00557414
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
The purpose of this study is to determine the impact of the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) on etiology and prognosis of acute respiratory distress syndrome (ARDS)
- Detailed Description
The triggering receptor expressed on myeloid cells-1 (TREM-1), a member of the immunoglobulin superfamily, is upregulated on phagocytic cells in the presence of bacteria or fungi infection and weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form (sTREM-1) in body fluids. The level and serial change of a serum sTREM-1 from cirtical ill patients has been shown to be a good diagnostic and prognostic indicator of ventilation associated pneumonia (VAP) and severe sepsis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 63
- Fulfill clinical diagnosis of ARDS
- Require mechanical ventilation support
- Pregnant
- Immunocompromised
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Septic or non-septic etiology At enrollment all cause mortality 28 days
- Secondary Outcome Measures
Name Time Method IL-1 beta, IL-8, TNF-alpha serial follow up at Day 1, 3, 5, 7, 14 CRP, lactate, WBC count, APACHE II score, LIS, SOFA score At enrollment
Trial Locations
- Locations (1)
National Taiwan University Hospital
🇨🇳Taipei, Taiwan