Serial Changes of sTREM-1 Levels in Patients With Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Septic or non-septic etiology
研究概览
简要总结
The purpose of this study is to determine the impact of the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) on etiology and prognosis of acute respiratory distress syndrome (ARDS)
详细描述
The triggering receptor expressed on myeloid cells-1 (TREM-1), a member of the immunoglobulin superfamily, is upregulated on phagocytic cells in the presence of bacteria or fungi infection and weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form (sTREM-1) in body fluids. The level and serial change of a serum sTREM-1 from cirtical ill patients has been shown to be a good diagnostic and prognostic indicator of ventilation associated pneumonia (VAP) and severe sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fulfill clinical diagnosis of ARDS
- •Require mechanical ventilation support
排除标准
- •Immunocompromised
结局指标
主要结局
Septic or non-septic etiology
时间窗: At enrollment
all cause mortality
时间窗: 28 days
次要结局
- IL-1 beta, IL-8, TNF-alpha(serial follow up at Day 1, 3, 5, 7, 14)
- CRP, lactate, WBC count, APACHE II score, LIS, SOFA score(At enrollment)