A Phase 1, Open-Label, First-in-Human Study to Evaluate the Safety and Anti-tumour Activity of FS222, a CD137/PD-L1 Bispecific Antibody, in Subjects With Advanced Malignancies
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 260
- 试验地点
- 21
- 主要终点
- Determination of a recommended Phase 2 dose (RP2D) by evaluation of DLTs
研究概览
简要总结
This study will be conducted in adult participants diagnosed with advanced tumours to characterize the safety, tolerability, pharmacokinetics (PK), and activity of FS222. This is a Phase 1, multi-center, open label, multiple-dose, first in human study, designed to systematically assess safety and tolerability, and to identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) for FS222 in participants with advanced tumours. Pharmacokinetics, pharmacodynamics, immunogenicity, and response will also be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •Participants with histologically or cytologically confirmed, locally advanced, unresectable or metastatic solid tumours for whom standard therapy has proven to be ineffective, intolerable or is considered inappropriate. This criterion does not apply to the PK/PD expansion cohort, where tumour-specific criteria will apply instead.
- •No more than 1 line of prior therapy with ICB treatment. Exceptions as defined in protocol for PK/PD expansion cohorts will apply.
- •Participants who have received prior ICB, or any concurrent chemotherapy, radiotherapy, investigational, biologic or hormonal therapy for cancer treatment may be eligible for enrolment following a washout period.
- •Participants who have received prior anti-PD-L1 therapy are eligible if PD-L1 therapy was discontinued ≥6 months prior to entry into the study.
- •Participants who have failed a prior ICB regimen should document it.
- •Measurable disease. Exceptions as defined in protocol for PK/PD expansion cohorts will apply.
- •Eastern Cooperative Oncology Group Performance Status ≤
- •The participant agrees to undergo a mandatory pre-treatment and on-treatment biopsy of the tumour. Certain exceptions apply.
- •Highly effective contraception.
- •Willing and able to provide written informed consent.
排除标准
- •Participants with clinically relevant COVID-19 disease risk will be excluded from enrolment during the COVID-19 pandemic.
- •Concurrent enrolment in another clinical study with the exception of non-interventional/observational studies or the follow-up period of an interventional study.
- •Prior treatment with CD137 agonist mAb or other experimental agonists.
- •For participants who have received prior ICB, participants must not have received more than 1 line of prior treatment with ICB(s). Exceptions as defined in protocol for PK/PD expansion cohorts will apply.
- •Participants with active autoimmune disease.
- •Receipt of any live virus vaccine within 30 days prior to the first dose of study drug.
- •Receipt of a live attenuated vaccine within 30 days prior to the first dose of study drug.
- •History of uncontrolled intercurrent illness.
- •Psychological, familial, sociological or geographical conditions that do not permit compliance with the protocol.
- •Judgment by the investigator that the participant is unsuitable to participate in the study, and the participant is unlikely to comply with study procedures, restrictions and requirements.
- •Significant laboratory abnormalities.
- •Known infections.
- •Uncontrolled CNS metastases, primary CNS tumours with CNS metastases as only measurable disease. Exceptions as defined in protocol for PK/PD expansion cohorts will apply.
- •Prior history of any Grade ≥3 irAE that has not improved to Grade ≤1, except for endocrine deficiencies that are managed by HRT; significant treatment-related cytokine release syndrome; systemic inflammatory response syndrome.
- •Current use of immunosuppressive agents, prior organ transplantation requiring immunosuppression, hypersensitivity or intolerance to mAb or their excipients, or persisting toxicity related to prior therapy of Grade >1 NCI CTCAE Version 5.0 .
研究组 & 干预措施
FS222 Q4W
The initial cohorts will enroll sequentially as single participant cohorts. If no DLT or ≥Grade 2 study drug related adverse event is observed, then dosing will proceed in a 3+3 design. Additional participants will be recruited into the PK/PD expansion cohorts at dose levels deemed safe during dose escalation. Once a tolerated dose has been established participants will be recruited into tumour-specific expansion cohorts.
干预措施: FS222 (Drug)
结局指标
主要结局
Determination of a recommended Phase 2 dose (RP2D) by evaluation of DLTs
时间窗: 28 days
Toxicity will be evaluated according to the NCI CTCAE Version 5.0.
Presence of adverse events (AEs) and serious adverse events (SAEs)
时间窗: 15 months
Safety and tolerability will be evaluated by collection of AEs and SAEs according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 5.0.
Determination of a maximum tolerated dose (MTD) by evaluation of DLTs
时间窗: 28 days
Toxicity will be evaluated according to the NCI CTCAE Version 5.0.
次要结局
未报告次要终点