Comparative Evaluation of Condylar Changes in Temporomandibular Joint Disorder Patients Assessed by Salivary Biomarkers MMP3, IL1Î’, and PAI1
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Compare the level of MMP3, IL1β, PAI1 in TMD patients before
研究概览
简要总结
Temporomandibular joint disorder is commonly diagnosed
with radiographic imaging modalities like Computed Tomography (CT),
Cone Beam Computed Tomography (CBCT), Orthopantomagram
(OPG) etc. The most popular among these is CBCT. Considerable
amount of bony loss (30%) should happen in order to become visible
through radiograph , so we need to have new diagnostic approaches
which might help in early detection of bony disorders. Biomarkers,
which are naturally occurring biological molecule found in blood,
saliva or other body fluids can be used. They reveal inflammation,
angiogenesis and tissue destruction that correlates with bone
resorption and repair. Assessing salivary biomarkers will show real
time changes and also predict future resorption which helps us to
start with treatment as early as possible.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 30.00 Year(s)（—）
- 性别
- Female
入选标准
- •Patients on clinical examination who met RDC TMD criteria I Female patients.
排除标准
- •Congenital craniofacial disorders Previous treatment for TMJ disorders Previous orthodontic treatments History of trauma to the TMJ area.
结局指标
主要结局
Compare the level of MMP3, IL1β, PAI1 in TMD patients before
时间窗: 5 months
and after treatment.
时间窗: 5 months
Compare the level of MMP3, IL1β, ,PAI1 in healthy and TMD patients
时间窗: 5 months
次要结局
- To determine the level of MMP3, IL1β,PAI1 in healthy patients(To determine the level of MMP3, IL1β,PAI1 in TMD patients)
研究者
Gibi Babu Philip
Azeezia Dental College