跳至主要内容
临床试验/NCT03198910
NCT03198910已完成不适用

Efficacy of Medical Therapy for Pulmonary Arterial and Inoperable Chronic Thromboembolic Pulmonary Hypertension in a Real Life Setting

University of Zurich1 个研究点 分布在 1 个国家目标入组 313 人开始时间: 2017年6月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
313
试验地点
1
主要终点
Change in NT-proBNP

研究概览

简要总结

The collected data from the Zurich Registry for pulmonary Hypertension (PH) are evaluated in a retrospective analysis. This study examines the number of patients and their exact diagnoses who are treated at the University Hospital of Zurich and potentially other participating in the Zurich Registry. Other demographic parameters such as age, gender and body-mass-index are also part of the evaluation. Furthermore, the analysis will focus on the newest guidelines on PH. Therefore, it will be checked how many patients would fulfill the therapeutic goals in terms of New York Heart Classification (NYHA), 6-minute walk distance, sign of right heart failure and N-terminal pro-brain-natriuretic peptide(NTproBNP). Additionally, the study examines on how the patients are treated. Despite the different kind of Drugs, the focus lies on the combination therapy (single, double, triple) and the impact the therapy had on the patients.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with pulmonary arterial hypertension (PAH)
  • Patients with chronic thromboembolic pulmonary hypertension (CTEPH)
  • All prevalent patients (diagnosed >12 month ago) with PAH or distal CTEPH who had a consultation at the PH centre in Zurich between November 2015 and November 2016)

排除标准

  • 未提供

结局指标

主要结局

Change in NT-proBNP

时间窗: Baseline, 3 months, 6 months, 1 year

Change of the 6 minute walk distance over time in relation to given vasodilator treatment

Change in NYHA/WHO functional class

时间窗: Baseline, 3 months, 6 months, 1 year

Change of the functional class over time in relation to given vasodilator treatment

Change in 6 minute walk distance

时间窗: Baseline, 3 months, 6 months, 1 year

Change of the 6 minute walk distance over time in relation to given vasodilator treatment

次要结局

  • Percentage of patients with a 6 minute walk distance > 440m(Baseline, 3 months, 6 months, 1 year)
  • Percentage of patients that are in NYHA/WHO functional class <= II(Baseline, 3 months, 6 months, 1 year)
  • Percentage of patients with a NT-proBNP < 300 ng/l(Baseline, 3 months, 6 months, 1 year)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验