Outcome of Cardiac Arrest Survivors
- Conditions
- Cardiac Arrest Survivors
- Interventions
- Other: Long-term follow-up
- Registration Number
- NCT02494414
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Early prognosis of cardiac arrest - nearly 40000 new cases per year in France - has been extensively studied, highlighting a poor outcome (less than 8% at hospital discharge). However, little is known on mid and long-term prognostic factors and how these patients do survive from the event.
Using a regional cohort, the aim of the study is to describe long-term survival rate of cardiac arrest survivors, and to assess the influence of treatment strategies on survival and functional outcome.
- Detailed Description
The collection of clinical and biological data of patients who experienced cardiac arrest and survive from hospital, including a regular follow-up with qualitative data (functional, neurological and quality of life) may provide important benchmark on the evolution of these patients and on the impact of acute interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective treatments).
Using a large identified cohort of survivors of cardiac arrest, we aim to describe the qualitative long-term prognosis of these cardiac arrest patients (functional, neurological and quality of life status). Secondarily, we intend to identify the long-term prognostic factors, and particularly the role of early interventions, using a long-term and qualitative combined endpoint (vital status, functional scales, SF36).
This project is observational and will include all patients over 18 admitted alive after non-traumatic cardiac arrest in the area of Ile-de-France (France), whatever the cause of the cardiac arrest. Patients or their proxies, refusing their participation, will not be included.
We will collect all pre- and in-hospital information related to the event and performs prospectively interviews at 3 months and every year anniversary. The questionnaire will include vital status, cardiovascular events, medication and a complete qualitative report (SF36, ADL scale, OPC, CPC, social-professional activities).
This project will provide important data over time on the evolution of these patients. Findings will help in measuring the role of different strategies on long-term prognosis and consequently improve the overall management of cardiac arrest.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 601
- Patients alive after resuscitation from a out-of-hospital cardiac arrest
- All causes for cardiac arrest
- Age above 18
- Informed consent from the patient or next of kin
- Impossibility for communication after hospital discharge, whatever the cause (language, residence...)
- Follow-up refusal from the patient or next of kin
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description French prospective cohort of cardiac arrest survivors Long-term follow-up Outcome of cardiac arrest survivors: prospective cohort of Ile-de-France
- Primary Outcome Measures
Name Time Method Cerebral Performance Categories Scale at last follow-up (48 months max) Combined vital and neurological status
- Secondary Outcome Measures
Name Time Method SF-36 (Short-Form General Health Survey) at last follow-up (48 months max) Quality of life
Overall Performance Categories (OPC) at last follow-up (48 months max) Activities of Daily Living (ADL) scale at last follow-up (48 months max) New cardiovascular events at last follow-up (48 months max) New York Heart Association (NYHA) status at last follow-up (48 months max)
Trial Locations
- Locations (1)
INSERM U970 Centre de Recherche Cardiovasculaire de Paris Equipe 4, Epidémiologie Cardiovasculaire et Mort Subite
🇫🇷Paris, France