To compare efficacy of Turmeric, Friendly Bacteria, and Fluoride based mouth rinses in children
- Conditions
- Dental caries, unspecified,
- Registration Number
- CTRI/2022/07/043936
- Lead Sponsor
- SGT University
- Brief Summary
Use of mouth rinses along with daily brushing and flossing is useful for maintaining dental oral hygiene. They help in reaching areas not easily accessed by a toothbrush and may further reduce the disease risk like arresting plaque accumulation, gingival inflammation, dental caries, and others risk used to reduce the microbial load in the mouth.
Streptococcus mutans has been associated with increased caries risk which is a gram-positive bacterium. Of all cariogenic microorganisms, S. mutans has many virulent factors such as producing acids from carbohydrates, tolerating an extreme acidic environment, and producing extracellular polysaccharides, which facilitate their adherence to other bacteria and tooth surfaces. These are acidogenic and form long-chain high molecular mass polymers which is an important virulent factor in the cariogenicity of S. Mutans.
Curcumin is a natural plant present in the curcuma longa. Previous studies have stated that the use of curcumin could decrease the biofilm activity of s. Mutans as they are inhibitors of quorum sensing in bacteria. It is an herbal and natural product that has no side effects. It is an antibacterial of S. Mutans.
Probiotics are dietary substances that compose bacteria or potentially useful fungi. They are being widely researched in bacteriotherapy. Bacteriotherapy is the method of harmonizing oral ecology and reducing the no. of cariogenic bacteria by an alternative approach. It has been found useful in reducing the amount of salivary S. Mutans and dental plaque, further reducing cariogenesis.
Fluoride is widely used in dentistry to control caries at either the community or individual levels. Scientific evidence exists on caries management through effective therapeutic interventions like fluoride.
Therefore, the aim of the present study is to compare the clinical efficacy of curcumin, probiotics. Once eligibility is confirmed according to the inclusion and exclusion criteria, the treatment procedure will be explained to the parent and after obtaining the consent from the parents the study will be conducted.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 45
- Children of age 7-9 years.
- Mixed dentition with erupted noncarious permanent central incisors and permanent 1st molars.
- High caries risk Children with dmft scoring ≤3.
- Children suffering from any systemic illness.
- Patients with reduced manual dexterity (children with special health care needs).
- Children who had taken any antibiotics in the last 14 days.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess antimicrobial efficacy of probiotic (VARUGUD LB), curcumin (0.1%), fluoride (0.05%) containing mouth rinses on mutans streptococci count by colony forming units and gingival health in 7-9 yr. old children. microbiological evaluation at baseline sample and 1 month sample | gingival evaluation at baseline sample , 1 month , 3 months,6 months ,9 months.
- Secondary Outcome Measures
Name Time Method - To compare the efficacy of curcumin (0.1%), probiotic (VARIGUD LB), fluoride (0.05%) containing mouth rinses clinically using Nyvad criteria, gingival index, plaque index and microbiologically on microbiologically on mutans streptococci count by colony forming units at baseline sample and after 1 month follow up sample in 7-9year old children. microbiological evaluation at baseline sample and 1 month sample
Trial Locations
- Locations (1)
SGT University, Budhera, Gurgaon 122505
🇮🇳Gurgaon, HARYANA, India
SGT University, Budhera, Gurgaon 122505🇮🇳Gurgaon, HARYANA, IndiaKarunaPrincipal investigator7988736798dr.karunatewatia@gmail.com