Cognition in Mindfulness: Negativity and Depression

Completed

Conditions: depression
10027946
major depressive disorder

Registration Number: NL-OMON50017

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 230

Inclusion Criteria

• Age: 18+ years old
• Chronic or recurrent major depressive disorder (MDD) diagnosis , both with
current episode or in remission
• Able to give informed consent

Exclusion Criteria

• Impossibility to obtain a valid informed consent
• Insufficient comprehension of the Dutch language
• Physical, cognitive, or intellectual impairments interfering with
participation, such as deafness, blindness, or sensorimotor handicaps
• Formerly/currently involved in MBCT or MBSR training
• Meets criteria for bipolar disorder, schizophrenia, schizophreniform
disorder, schizoaffective illness or anorexia nervosa.
• Current psychosis
• High level of suicidality
• Drug or alcohol addiction in the past 6 months

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our primary objective is to understand the role of rumination in depressive<br /><br>symptoms changes in chronic and recurrent MDD patients as a result of MBCT<br /><br>treatment. Therefore we will assess rumination and depressive symptoms<br /><br>repeatedly during MBCT and will investigate the effect of MBCT on a novel,<br /><br>on-line behavioural task of rumination, namely the Breathing Focus Task (BFT).<br /><br>We will also use questionnaires to assess rumination and depressive symptoms.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Our secondary aim is to elucidate the cognitive mechanisms concerning negative<br /><br>inhibitory processing in working memory and behaviour that possibly underlie<br /><br>depression and rumination and the effect of MBCT. For this, we will look at<br /><br>aversive PIT and evaluate its relation with depression. We will also test<br /><br>emotion specific working memory function and evaluate its relation with<br /><br>rumination. Additionally, the effect of MBCT on these parameters will be<br /><br>assessed.<br /><br><br /><br>For this we will use the Pavlovian-Instrumental Transfer (PIT) task and the<br /><br>Working Memory Update/Ignore Emotion Task (WMUIET), together with<br /><br>questionnaires and the BFT task to assess rumination.</p><br>