Dosage determination and efficacy of propofol and atracurium for rapid sequence induction of anesthesia: A randomized double-blind prospective study.
Phase 4
Completed
- Conditions
- Emergency surgery required rapid sequence induction of anesthesiaRapid sequence induction,intubation,atracurium,propofol
- Registration Number
- TCTR20170912003
- Lead Sponsor
- The Royal College of Anesthesiologists of Thailand (RCAT)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 122
Inclusion Criteria
1. Patients undergoing elective surgery, aged 20-65 years, and require general anesthesia
2. ASA physical status I-II
Exclusion Criteria
1. Patients required emergency surgery
2. Unstable vital signs
3. History of difficult intubation or anticipated difficult intubation
4. Patients with history of neuromuscular disease
5. On anticonvulsant medication for more than 1 month
6. History of asthma or use bronchodilators
7. History of allergy to medications used in the study
8. Obesity, BMI >30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intubating condition 1 minute after drug administration Likert scale for vocal cord and diaphragm movement during intubation
- Secondary Outcome Measures
Name Time Method Muscle blockade of atracurium TOF=0 Train-of-four (TOF),Muscle power recovery time TOF=2 Train-of-four (TOF),Hemodynamic 10 minutes after study drug administration BP, HR,adverse effect from study drug 10 minutes after study drug admistration rash, bronchospasm (high airway pressure)