Within household transmission of SARS-CoV-2 infections, a multicentre prospective cohort-study

Completed

Conditions: 10024970
Coronavirus infection
COVID-19
10047438

Registration Number: NL-OMON52515

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 1500

Inclusion Criteria

Households are eligible if all members of the household or their legal
guardians consent to participation and 1) are willing to complete diaries and
questionnaires for the duration of follow-up, 2) are willing to, and capable of
self-sampling nose-throat swabs, saliva (if applicable) and capillary blood
samples by finger. If parents/caretakers of young children are reluctant to
take a blood sample from their child, this is no reason for exclusion.

For the substudy starting in November 2022 participants who have participated
in the household study will be eligible for the substudy.

Exclusion Criteria

Patients or household members who are unable to consent, or do not wish to
provide informed consent.
Children, pregnant women and patients lacking capacity will be included. Those
lacking capacity to consent for themselves will be identified and consent will
be sought from an appropriate consultee.
Households who do not have daily access to a smartphone or tablet with internet
connection, will be excluded, as follow-up of households requires the use of an
interactive diary App.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Estimate key transmission parameters of SARS-CoV-2 in Europe from observing<br /><br>within household virus spread and seroconversion of household members.<br /><br>o Household secondary attack rates<br /><br>o Transmission rate<br /><br>The secondary SARS-CoV-2 attack rate is defined as the number of secondary<br /><br>cases divided by the number of household members at risk (i.e. excluding the<br /><br>index case).<br /><br><br /><br>Substudy: Incidence rate of reinfections of SARS-CoV-2 and risk factors<br /><br>associated with the incidence of SARS-CoV-2 reinfections (demographic,<br /><br>clinical, virological and immunological).</p><br>

Secondary Outcome Measures