Randomized clinical trial to evaluate the utility of CYP2D6 genotyping to improve the efficacy and safety of tramadol in the treatment of acute postoperative pain - 1

Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa0 个研究点目标入组 300 人开始时间: 2022年4月18日最近更新: 2024年7月22日

适应症

试验速览

阶段: 1 期
状态: 招募中
发起方: Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa
入组人数: 300

暂无简介。

•1. Men or women over 18 years of age., 2. Patients scheduled for outpatient surgical extraction, under local anesthesia, of at least two impacted third molars, at least one of which will require bone removal., 3. Patients who agree to participate in the study and give written consent.

•1. Patients under treatment with other drugs that can inhibit CYP2D6, or are contraindicated in combination with tramadol or dexketoprofen., 2. Patients on treatment with bisphosphonates., 3. Patients who are receiving analgesic treatment before the operation, 24 hours prior to the operation. This criterion will be evaluated at the intervention visit., 4. Patients suffering from other uncontrolled diseases., 5. Pregnant or breastfeeding women., 6. Patients with contraindications for treatment with tramadol or dexketoprofen.

发起方