A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Gabapentin Extended Release (G-ER) Tablets in the Treatment of Patients With Postherpetic Neuralgia
Overview
- Phase
- Phase 3
- Intervention
- Gabapentin Extended Release tablets
- Conditions
- Neuralgia,Postherpetic
- Sponsor
- Depomed
- Enrollment
- 452
- Primary Endpoint
- Mean Change in Baseline Observation Carried Forward (BOCF) Average Daily Pain Score
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for effective pain control. The purpose of this study is to determine whether a new gabapentin tablet, which only needs to be taken once a day, is safe and effective for the treatment of postherpetic neuralgia.
Detailed Description
The primary study objective is to assess the relative efficacy of G-ER dosed once daily (1800 mg following the evening meal), versus placebo in reducing the mean daily pain score from the baseline week to the end of the efficacy treatment period (Treatment Week 10) in patients with PHN. Secondary efficacy measures will include changes from baseline in mean weekly sleep interference scores, Short-Form McGill Pain Questionnaire (SF-MPQ), the Neuropathic Pain Scale (NPS), Brief Pain Inventory (BPI), Patient Global Impression of Change (PGIC), and Investigator-Rated Clinical Global Impression of Change (CGIC).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men or women 18 years or older who have experienced pain for at least 6 months, but not more than 5 years after the healing of a herpes zoster skin rash(typically about 4 months after the rash first appears).
- •Patient has a pain intensity score of at least 4 on the 11-point Numerical Rating Scale (NRS). Patients should never be informed of the pain intensity criterion prior to screening or randomization.
- •Patients of child-bearing potential must have a negative serum pregnancy test at screening and a negative follow-up urine pregnancy test at randomization.
- •Patient has a mean baseline week pain intensity score of at least 4 on the 11-point NRS scale at the end of a 1-week baseline period and has completed at least 4 days of daily pain diary entries during the baseline week.
- •Patients must have a minimum washout period of greater than 5 times the half-life of the drug of several medications.
- •Patients currently treated with gabapentin pr pregabalin at screening may be eligible for the study, but must have a tapering period wherein the dose of gabapentin or pregabalin is reduced gradually over a period of 5 days followed by a two day washout prior to the Baseline Week.
Exclusion Criteria
- •Patients who have previously not responded to treatment for PHN with gabapentin or pregabalin.
- •Patients who previously experienced dose-limiting adverse effects that prevented titration of gabapentin to an effective dose.
- •Patient is a nursing mother.
- •Patient has hypersensitivity to gabapentin.
- •Patient has had neurolytic or neurosurgical treatment for PHN.
- •Patient has severe pain from causes other than PHN.
- •Patient has used injected anesthetics or steroids within 30 days of baseline.
- •Patient has skin conditions in the area affected by the neuropathy that could alter sensation.
- •Patient is in an immunocompromised state.
- •Patient has an estimated creatinine clearance less than 50 ml/min.
Arms & Interventions
G-ER
Gabapentin - Extended Release
Intervention: Gabapentin Extended Release tablets
Placebo
Sugar pill
Intervention: Placebo
Outcomes
Primary Outcomes
Mean Change in Baseline Observation Carried Forward (BOCF) Average Daily Pain Score
Time Frame: 10 weeks
Average daily pain scored on 11-point numerical rating scale (where 0 = no pain, 10 = worst possible pain). Results presented as least squares (LS) mean change in baseline observation carried forward (BOCF) average daily pain score from baseline to the final week of efficacy treatment period (Week 10).
Secondary Outcomes
- Patient Global Impression of Change (PGIC)(10 weeks)
- Average Daily Sleep Interference Score(10 weeks)
- Clinical Global Impression of Change (CGIC)(10 weeks)