NCT00006203已完成4 期
Naltrexone, Craving, and Drinking: Ecological Assessment
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
研究概览
简要总结
This 5-week study will examine the effects of naltrexone on alcohol craving, drinking rates, and reaction to drinking-related triggers, or cues, in participants' everyday environment and in laboratory sessions. Participants will monitor and record their daily desires to drink, environmental circumstances in which urges occur, and drinking behavior using a palm top computer. Participants will receive naltrexone or a placebo. One week after receiving medication, all participants will be asked to respond to alcohol-related cues that may or may not arouse the desire to drink.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Drink at least 4 days per week with 2 heavy drinking days (more than 6 standard drinks for men, more than 5 drinks for women) per week on average during the month prior to the study.
排除标准
- •Current interest in treatment or a history of treatment for alcohol problems.
- •History of liver disease or current liver function tests greater than five times normal.
- •Opiate abuse or dependence, any opiate use two weeks before the study or a urine test screen that is positive for opiates.
- •Females, who are pregnant, nursing, or not using reliable birth control method.
- •Daily use of acetaminophen.
- •Living with someone who participated in this study.
研究组 & 干预措施
Naltrexone Arm
Experimental
Three weeks of daily 50mg Naltrexone
干预措施: Naltrexone 50 Mg (Drug)
Placebo Arm
Placebo Comparator
Three weeks of daily placebo (sugar)
干预措施: Placebo (Drug)
研究者
研究点 (1)
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