TCTR20221117001
Not yet recruiting
Phase 3
A randomized controlled trial evaluating virologic and renal outcomes after switching from TDF/FTC/EFV to TDF/3TC/DTG (TLD) versus DTG/3TC in virologically suppressed Thai PWH
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Virologically suppressed HIVOn TDF/FTC/EFVCrCl more than 60 ml/min
- Sponsor
- Mahasarakham University
- Enrollment
- 268
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •HIV\-infected adults age of 18 years or more
- •Receiving TDF/FTC/EFV
- •Documented HIV VL \< 50 copies/mL in the past 12 months
Exclusion Criteria
- •History of documented HIV drug resistance
- •History of DTG hypersensitivity
- •Estimated glomerular filtration rate \< 60 ml/min
- •Cirrhosis CTP B or C
- •Currently on antituberculosis therapy
- •Receiving metformin \> 1000 mg/day
- •If available, initial HIV VL \> 500,000 copies/mL
- •Positive HBsAg
Outcomes
Primary Outcomes
Not specified
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