The evaluation of effectiveness of topical sesame oil on clinical symptoms in patients with knee osteoarthritis

Not Applicable

• Conditions: Knee osteoarthritis.; Gonarthrosis

• Registration Number: IRCT2017081711341N8
• Lead Sponsor: Vice chancellor for research, Fasa University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

the age between 30-70 years old; patient's written informed consent for inclusion; diagnosis of osteoarthritis by the orthopedist according to American College of Rheumatology classification criteria; grade I to III osteoarthritis according to Kellegren-Lawrence system of classification; pain of at least one knee during 3 months ago; no congenital abnormality of lower extremity.

Exclusion Criteria

hypersensitivity to Sesame Oil or Diclofenac gel or celecoxib; unwillingness to continue to participate in the study; secondary osteoarthritis due to rheumatologic diseases like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis; joint replacement; concomitant use of glucosamine and chondroitin sulfate; knee injection of corticosteroid or hyaluronic acid in the past 3 months; other articular corticosteroid or hyaluronic acid injection in the past 1 month; use of oral or topical analgesic drugs 3 days before enrollment; pregnancy or Lactating women; alcohol addiction; drug abuse; using oral or topical corticosteroid 14 days days before enrollment; skin lesions of knee; disability to cooperate in filling the forms (cognitive or language disorder); the patient who use drugs that interact with celexib (e.g. lithium, fluconazole, warfarin, diuretics, ACE inhibitors like captopril, ARBs like losartan); patient with IBD or PUD; obesity (BMI = 35 kg/m^2); use of physical modalities 2 weeks before enrollment (such as physical treatment, Acupuncture and Transcutaneous Electrical Nerve Stimulator).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
General status of pain, physical function and stiffness of patients. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.