Comparison of effectiveness of topical sesame oil with Diclofenac gel in patients with knee osteoarthritis

Vice chancellor for research, Fasa University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•the age between 30-70 years old; patient's written informed consent for inclusion; diagnosis of osteoarthritis by the orthopedist according to American College of Rheumatology classification criteria; grade I to III osteoarthritis according to Kellegren-Lawrence system of classification; pain of at least one knee during 3 months ago; no congenital abnormality of lower extremity.

•hypersensitivity to Sesame Oil or Diclofenac gel or celecoxib; unwillingness to continue to participate in the study; secondary osteoarthritis due to rheumatologic diseases like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis; joint replacement; concomitant use of glucosamine and chondroitin sulfate; knee injection of corticosteroid or hyaluronic acid in the past 3 months; other articular corticosteroid or hyaluronic acid injection in the past 1 month; use of oral or topical analgesic drugs 3 days before enrollment; pregnancy or Lactating women; alcohol addiction; drug abuse; using oral or topical corticosteroid 14 days days before enrollment; skin lesions of knee; disability to cooperate in filling the forms (cognitive or language disorder); the patient who use drugs that interact with celexib (e.g. lithium, fluconazole, warfarin, diuretics, ACE inhibitors like captopril, ARBs like losartan); patient with IBD or PUD; obesity (BMI = 35 kg/m^2); use of physical modalities 2 weeks before enrollment (such as physical treatment, Acupuncture and Transcutaneous Electrical Nerve Stimulator).

发起方

Vice chancellor for research, Fasa University of Medical Sciences