Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Neuroimaging Studies
研究概览
简要总结
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
详细描述
Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age≥18 years
- •Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂<150 mmHg,and requiring prone ventilation
- •Expected duration of mechanical ventilation>48 hours
- •Written informed consent obtained
排除标准
- •Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension)
- •Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics
- •Life-threatening ARDS
- •Patients who are unable to undergo neurological assessment
- •Poor image quality or absence of images
结局指标
主要结局
Neuroimaging Studies
时间窗: From enrollment to 2 weeks after the end of treatment.
Cranial CT or MRI Scans Conducted Before and After Prone Positioning to Detect New-Onset Neurological Complications Such as Cerebral Edema, Intracranial Hemorrhage, and Cerebral Infarction
Biomarker Detection
时间窗: From enrollment to 2 weeks after the end of treatment.
Blood samples were collected for NSE(Neuron-specific Enolase)and IL-6(Interleukin-6)before and after prone positioning.
次要结局
- Incidence rate of delirium(From enrollment to 2 weeks after the end of treatment.)
- Cognitive function(From enrollment to 2 weeks after the end of treatment.)
研究者
Lingai Pan
Deputy Chief Physician
Sichuan Provincial People's Hospital