Clinical evaluation of receptor for advanced glycation endproducts (RAGE) as a biomarker for lung injury
Not Applicable
- Conditions
- Patients undergoing cardiac surgery
- Registration Number
- JPRN-UMIN000010674
- Lead Sponsor
- Department of Anesthesiology, Tokyo Medical and Dental University, Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Not provided
Exclusion Criteria
Preoperative exclusion criteria were: 1) patient's age < 20 years; 2) history of myocardial infarction within 30 days before the day of surgery; 3) preoperative diagnosis of pneumothorax; 4) diagnosis of chronic obstructive pulmonary disease; 5) neuromuscular disease; 6) morbidly obese (body mass index > 40); and 7) systemic connective tissue disease. Postoperative exclusion criteria were: 1) severe neurological complications requiring mechanical ventilation; 2) the need for an extracorporeal circuit due to cardiac failure; and 3) patients whose pulmonary artery occlusion pressure (PAOP) was >18 mm Hg in the first postoperative week.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relationship between RAGE levels and duration of mechanical ventilation
- Secondary Outcome Measures
Name Time Method Relationships between RAGE and other biomarker proteins (interleukin-8, S100/A12, Angiopoietins, von Willbrand factor antigen, HMGB1 etc)