A MRI-based Study of Ischaemic Penumbra: the Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
研究概览
简要总结
Previous research has shown there wasn't inevitable relationship between mismatch area and infarct growth according to Volumetric-subtraction mismatch volume.The recently published on Stroke paper has proposed Coregistration mismatch to calculate the mismatch to replace ischaemic penumbra, and it reignites hope for clinical application of the PWI/DWI mismatch. But the correlation between the mismatch, calculated by Coregistration mismatch method,and the clinical outcome of the patients with acute ischemic stroke is still unknown. so the investigators plan to conduct a prospective observational cohort study.
详细描述
NIHSS,mRS and MR PWI/DWI/MRA are performed within 48 hours of stroke onset and final MR T2/flair image at ≈1 month. And then,Volumetric-subtraction mismatch and Coregistered mismatch will be calculated,respectively.finally,we will assess and compare the Volumetric-subtraction mismatch and Coregistered mismatch, and to clarify which method match the clinical outcome more better.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged eighteen or above
- •Acute middle cerebral artery ischemic stroke
- •Stroke onset within 48 hours
- •Included a complete set of initial MR images and final outcome MR images up to 1 months
排除标准
- •History of stroke in the past 6 weeks
- •Pre-existing neurological or psychiatric disease that could confound the study results such as a pre-stroke mRS score greater than 3
- •CT evidence of the following conditions before enrollment:
- •Significant mass effect with midline shift Evidence of intracranial hemorrhage
- •With contraindication to MR such as severe allergy to contrast media