Effects of psychotherapy on brain activity in patients with borderline personality disorder in comparison with controls: a functional magnetic resonance study.

Not Applicable

Recruiting

• Conditions: Borderline Personality Disorder; Mental Health - Psychosis and personality disorders

• Registration Number: ACTRN12619000078156
• Lead Sponsor: Department of Neuroscience, University of Turin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-21
• Last Update Posted: 28 January 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Subjects included in the study have all right handed dominance (assessed with the Edinburgh Handedness Inventory. Diagnosis of borderline personality disorder (BPD) is made by an expert clinician and is confirmed with the Structured Clinical Interview for DSM.IV AxisII Disorders. Healthy subjects are recruited among general population, and are matched for age and gender.

Exclusion Criteria

Exclusion criteria are: diagnoses of dementia, delirium, and other cognitive disorders; neurological diseases; schizophrenia and other psychotic disorders; bipolar disorders; concurrent major depressive episode; substance abuse in the last two months; pharmacological treatments in the last 3 weeks. Female patients of childbearing age were excluded if they were not using adequate birth control methods (according to the judgment of clinicians).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
As in the previous study registered in ANZCTR, primary outcome was brain functioning changes during the fMRI in the regions of interest (dorsolateral prefrontal cortex, insula, anterior cingulate cortex, and temporal parietal Junction) during the recall of significant life events.These data will be inserted into the Statistical Parametrical Mapping (SPM), a specific program to elaborate fMRI data. <br>[At baseline (T0) and after 40 weeks]

Secondary Outcome Measures

Name	Time	Method
evel of identity integration measured with the Identity disturbance questionnaire (IDQ) score [At baseline (T0) and after 40 weeks];Specific BPD symptoms assessed with the Borderline Personality Disorder Severity Index (BPDSI) score[At baseline (T0) and after 40 weeks];Changes in the Barratt Impulsiveness Scale -Version 11 (BIS-11)score [At baseline (T0) and after 40 weeks];Frequency of self-injuries measured with the Changes in the Self-Harm Inventory (SHI) score[At baseline (T0) and after 40 weeks];Aggressive Behaviors assessed with the Modified Overt Aggression Scale (MOAS) score[At baseline (T0) and after 40 weeks];Global symptoms measured with the Clinical Global Impression- Severity (CGI-S) scale.[At baseline (T0) and after 40 weeks]