The concentration measurement of acetaldehyde in human esophagus
Not Applicable
- Conditions
- normal condition
- Registration Number
- JPRN-UMIN000019991
- Lead Sponsor
- Division of Gastroenterology, Tohoku University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1. Current smoker 2. The subjects after resection of gastrointestinal tract or truncal vagotomy 3. The subjects with ongoing therapy for any disease 4. The subjects with taking drugs except for L-cysteine troches during this study 5. The subjects who cannot drink any alcohol 6. The subjects with past history of allergy for any drug 7. The subjects with past history of liver, kidney or heart disease 8. The subjects that this study researcher regards as inappropriate for participating in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The comparison of acetaldehyde concentration in esophageal biopsy specimen after alcohol intake between ALDH2-active and ALDH2-deficient subjects
- Secondary Outcome Measures
Name Time Method 1. The comparison of acetaldehyde concentration in esophageal biopsy specimen after alcohol intake between ALDH2-active and ALDH2-deficient subjects in administrating slowly L-cysteine releasing troches 2. The comparison of acetaldehyde concentration in blood, saliva, and esophageal biopsy specimen of ALDH2-active and ALDH2-deficient subjects in each condition of administration of slowly L-cysteine releasing troches and non-administration 3. The comparison of acetaldehyde concentration in esophageal and gastric biopsy specimen in each condition of administration of slowly L-cysteine releasing troches and non-administration