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临床试验/CTRI/2024/09/074235
CTRI/2024/09/074235尚未招募不适用

Study of uterine artery blood flow parameters in embryo transfer patients and its reproductive outcomes

V Nivedita Sivadas1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2024年12月5日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
150
试验地点
1
主要终点
Uterine artery pulsatality index,Uterine artery resistance index,

研究概览

简要总结

Data will be collected from patients who are willing to give consent. Baseline characteristics will age, BMI, type of infertility, obstetrics history, cause of infertility. known comorbidities. embryo transfer protocols. blood hormone values which are routinely done during the course of treatment will be noted.

Transvaginal ultrasound colour doppler of uterine artery will be measured on the day of ovulation trigger for fresh embryo transfer patients. For frozen embryo transfer patients same will be measured on the day of progesterone gel initiation. The measurements are taken along with the routine ultrasound scan which is done for patients during this time. Pulsatality index , resistance index, peak systolic velocities of both uterine arteries and its mean will be measured. Endometrial thickness , endomterial vascularity, number of embryos transferred , grade of embryos will be noted.

As standard procedure , patients will be called after 14 days of embryo transfer to measure serum beta hcg values . clinical pregnancy is determined by the presence of gestational sac on ultrasound for positive beta hcg patients at 6 weeks of gestation.This will also be noted.

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 40.00 Year(s)(—)
性别
Female

入选标准

  • Women aged 18-40 Patients willing to give consent Fresh embryo transfer Frozen embryo transfer Mild male factor infertility Tubal factor infertility Unexplained infertility.

排除标准

  • Uterine malformation Cavity distorting fibroid uterus Intra Uterine adhesions Tuberculosis Grade 3 embryo transfer PGT couples Adenomyosis.

结局指标

主要结局

Uterine artery pulsatality index,Uterine artery resistance index,

时间窗: Baseline,2 weeks, 6 weeks

Peak systolic velocity of uterine artery

时间窗: Baseline,2 weeks, 6 weeks

次要结局

  • Serum beta hcg(Clinical pregnancy rate.)

研究者

发起方
V Nivedita Sivadas
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

V Nivedita Sivadas

Kasturba Medical college Manipal, MAHE, Manipal

研究点 (1)

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