Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites
Not Applicable
Completed
- Conditions
- P. Falciparum Malaria
- Interventions
- Biological: Exposure to 5 P. falciparum infected mosquitoes
- Registration Number
- NCT00757887
- Lead Sponsor
- Radboud University Medical Center
- Brief Summary
In the EHMI-8 study (CMO 2006/207) the investigators induced sterile protection against P. falciparum challenge in healthy Dutch volunteers by repeated exposure to infected mosquitoes whilst under chloroquine prophylaxis. The surprisingly efficient induction of protection in this study strongly supports the development of whole parasite vaccines and is therefore an important finding to malaria vaccine development. In this study (EHMI8B) the investigators would like to explore the longevity of the protective immune response and simultaneously further characterise immune mechanisms responsible for protection by re-exposing EHMI-8 volunteers to infected mosquito bites.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description EHMI8 Exposure to 5 P. falciparum infected mosquitoes Previously protected volunteers, N=10 control Exposure to 5 P. falciparum infected mosquitoes 5 malaria-naive volunteers
- Primary Outcome Measures
Name Time Method A difference in occurrence of signs or symptoms between EHMI-8 and control volunteers 21 days A significant difference in time of thick smear positivity between EHMI-8 and control volunteers 21 days A significant difference in kinetics of parasitemia between EHMI-8 and control volunteers as measured by PCR. 21 days A significant quantitative difference in parasitemia as measured by PCR between EHMI-8 and control volunteers 21 days
- Secondary Outcome Measures
Name Time Method Difference in immunological parameters between EHMI-8 and control volunteers. 140 days
Trial Locations
- Locations (1)
UMC St. Radboud
🇳🇱Nijmegen, Netherlands