Tranexamic acid versus Misoprostol in reducing blood loss during cesarean section: a cross-sectional comparative study in Abakaliki, Nigeria
- Conditions
- Pregnancy and Childbirth
- Registration Number
- PACTR201910644489698
- Lead Sponsor
- Christian O OGAH
- Brief Summary
The maternal demographic and obstetrics factors and blood loss determinants like bedside clotting time, duration of surgery and cadre of surgeon during cesarean section were statistically non-significant between the two groups. Mean intraoperative blood loss was not significantly different between the misoprostol group and tranexamic acid group (547 ± 183.75ml vs. 551.66 ± 21.74ml, P = 0.519). The mean difference in PCV changes was not significant between the groups (2.41±0.95% vs. 2.29±0.56%, P = 0.463). Side effect profile was similar for both groups except shivering which was statistically higher among the misoprostol group compared to the tranexamic acid group (RR = 0.70; 95%CI 0.40 - 0.91, P = 0.028). From this study, tranexamic acid was comparable to misoprostol in the reduction of blood loss during cesarean section. Therefore, tranexamic acid could act as a good alternative to misoprostol for prophylaxis for blood loss during elective cesarean section.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 358
Booked women
Elective cesearean section
Previous cesarean section
Hypertensive disorders of pregnancy
Known allergy to misoprostol or tranexamic acid
Antepartum haemorrhage
Emergency caesarean section
Bleeding disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome: Quantity of blood loss during ceserean section<br><br>
- Secondary Outcome Measures
Name Time Method Secondary outcome: Need for blood transfusion<br> Need for additional intervention to control blood loss<br> Change in haemoglobin concentration 48hours after surgery<br> Change systemic blood pressure 4 hours after surgery