Haemochromatosis and Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- prevalence of periodontal diseases
研究概览
简要总结
Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth. It is strongly associated with the major pathogenic "red complex", including Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola1 and thus is considered an infection. Recent advances in the pathogenesis of periodontal disease have suggested that polymicrobial synergy and microbiota dysbiosis together with a dysregulated immune response can induce inflammation-mediated damage in periodontal tissues2-4. Interestingly, currently periodontitis is associated with a growing number of systemic diseases, including cardiovascular diseases, adverse pregnancy outcomes, diabetes5-7 and hereditary haemochromatosis8.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 35 to 64 years with homozygosity hemochromatosis C282Y
- •Patients regularly enrolled in a health insurance plan
- •Patients with at least 10 natural teeth
- •Patients who have given informed written, dated and signed consent
排除标准
- •Diabetic patients
- •Simultaneous participation in another study
- •Pregnant or lactating women
- •The incapacitated persons and persons deprived of their liberty
- •Patients who do not speak French, both written and spoken
- •Patients previously included in this trial
- •Patients with heart valves or endovascular equipment (risk of infective endocarditis ...)
- •Patients with a history of maxillofacial surgery
- •Patients whose oral status is considered incompatible with entry into the study, at the discretion of the investigator
- •Patients on drugs that can cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin
- •Patients on medication that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin).
研究组 & 干预措施
diagnostic test
干预措施: dental probes (Diagnostic Test)
结局指标
主要结局
prevalence of periodontal diseases
时间窗: 2 years
To evaluate the prevalence of periodontal diseases in patients with hemochromatosis at the time of diagnosis and / or their usual therapeutic
次要结局
未报告次要终点